Publications

 In date order (starting with most recent):

Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.

Eur J Pharmacol. 780:53-64.Epub 2016 Mar 17. PubMed PMID: 26997367. 5 June 2016.
DOI: 10.1016/j.ejphar.2016.03.031

Boland K, Flanagan L, McCawley N, Pabari R, Kay EW, McNamara DA, Murray F, Byrne AT, Ramtoola Z, Concannon CG, Prehn JH.

» read more

 

Modelling tumour cell proliferation from vascular structure using tissue decomposition into avascular elements.

J Theor Biol. pii:S0022-5193(16)30056-X. [Epub ahead of print]. PubMed PMID: 27155046. 4 May 2016.
DOI: 10.1016/j.jtbi.2016.04.028

Besenhard MO, Jarzabek M, O'Farrell AC, Callanan JJ, Prehn JH, Byrne AT, Huber HJ.

» read more

 

Colorectal Tumour Simulation using Agent Based Modelling and High Performance Computing

Future Generation Computer Systems (In Press)

Guiyeom Kang, Claudio Marquez, Ana Barat, Annette T. Byrne, Jochen H.M. Prehn, Joan Sorribes & Eduardo Cesar.


» read more

 

Mechanistic interrogation of combination Bevacizumab/dual PI3K/mTOR inhibitor response in Glioblastoma implementing novel MR and PET imaging biomarkers.

European Journal of Nuclear Medicine and Molecular Imaging (In Press).

Philip J O'Halloran, Thomas Viel, David W Murray, Lydia Wachsmuth, Katrin Schwegmann, Stefan Wagner, Klaus Kopka, Monika A Jarzabek, Patrick Dicker, Sven Hermann, Cornelius Faber, Tim Klasen, Michael Schäfers, David O'Brien, Jochen HM Prehn, Andreas H Jacobs and Annette T. Byrne.


» read more

 

Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant.

British Journal of Cancer 114, Pages 188-198, 19 January 2016
DOI: 10.1038/bjc.2015.420

Zakaria Z, Tivnan A, Flanagan L, Murray DW, Salvucci M, Stringer BW, Day BW, Boyd AW, Kögel D, Rehm M, O'Brien DF, Byrne AT, Prehn JH.

» read more

 

Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase 3 GeparQuinto study.

International Journal of Cancer Vol 137: 12, pages 2981-2988, 15 December 2015.
DOI: 10.1002/ijc.29656

Alexander Hein, Diether Lambrechts et al


» read more

 

Integrating Colon Cancer Microarray Data: Associating Locus-Specific Methylation Groups to Gene Expression-Based Classifications

Microarrays 4(4), 630-646, 23 November 2015.
DOI: 10.3390/microarrays4040630

Ana Barat, Heather J. Ruskin, Annette T. Byrne and Jochen H. M. Prehn.


» read more

 

Evaluation of efficacy and safety markers in a phase II study of metastatic colorectal cancer treated with aflibercept in the first-line setting.

British Journal of Cancer 113, pages 1027-1034, 29 September 2015.
DOI: 10.1038/bjc.2015.329

Diether Lambrechts, Bernard Thienpont, Vincent Thuillier, Xavier Sagaert, Matthieu Moisse, Gilian Peuteman, Carles Pericay, Gunnar Folprecht, John Zalcberg, Chiara Zilocchi, Emmanuelle Margherini, Marielle Chiron and Eric Van Cutsem


» read more

 

Reduced rate of copy number aberrations in mucinous colorectal carcinoma

Oncotarget Vol. 6:28 pages 25715-25725, 21 September 2015
DOI: 10.18632/oncotarget.4706

Niek Hugen, Femke Simmer, Leonie J.M. Mekenkamp, Miriam Koopman, Evert van den Broek, Johannes H.W. de Wilt, Cornelis J.A. Punt, Bauke Ylstra, Gerrit A. Meijer, Iris D. Nagtegaal.

» read more

 

Biomarker-driven Studies in Metastatic Colorectal Cancer (mCRC): Challenges and Opportunities

The Journal of OncoPathology, Vol 2:4, pages 37-45(9). November 2014
DOI: 10.13032/tjop.2052-5931.100113.

Van Cutsem, Eric; Prager, Gerald; Sargent, Daniel; Byrne, Annette T.; Huber, Heinrich J.; Middleton, Gary; Khan, Khurum; De Mattos-Arruda, Leticia; Seufferlein, Thomas.


» read more