In date order (starting with most recent):

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

Nature Communications volume 9, Article number: 4112 (2018) . DOI: 10.1038/s41467-018-06567-6 Dominiek Smeets, Ian S. Miller, [...] Annette T. Byrne (access full list of authors via link below). » read more


Anti-angiogenic drug scheduling optimisation with application to colorectal cancer

Scientific Reports volume 8, Article number: 11182 (2018) DOI: M. Sturrock, I. S. Miller, G. Kang, N. Hannis Arba'ie, A. C. O'Farrell, A. Barat, G. Marston, P. L. Coletta, A. T. Byrne & J. H. Prehn » read more


Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab

Journal of Clinical Oncology - published online before print May 24, 2018. DOI: 10.1200/JCO.2017.77.1782 Erik van Dijk et al » read more


Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.

Eur J Pharmacol. 780:53-64.Epub 2016 Mar 17. PubMed PMID: 26997367. 5 June 2016.
DOI: 10.1016/j.ejphar.2016.03.031

Boland K, Flanagan L, McCawley N, Pabari R, Kay EW, McNamara DA, Murray F, Byrne AT, Ramtoola Z, Concannon CG, Prehn JH.

» read more


Modelling tumour cell proliferation from vascular structure using tissue decomposition into avascular elements.

J Theor Biol. pii:S0022-5193(16)30056-X. [Epub ahead of print]. PubMed PMID: 27155046. 4 May 2016.
DOI: 10.1016/j.jtbi.2016.04.028

Besenhard MO, Jarzabek M, O'Farrell AC, Callanan JJ, Prehn JH, Byrne AT, Huber HJ.

» read more


Colorectal Tumour Simulation using Agent Based Modelling and High Performance Computing

Future Generation Computer Systems (In Press)

Guiyeom Kang, Claudio Marquez, Ana Barat, Annette T. Byrne, Jochen H.M. Prehn, Joan Sorribes & Eduardo Cesar.

» read more


Mechanistic interrogation of combination Bevacizumab/dual PI3K/mTOR inhibitor response in Glioblastoma implementing novel MR and PET imaging biomarkers.

European Journal of Nuclear Medicine and Molecular Imaging (In Press).

Philip J O'Halloran, Thomas Viel, David W Murray, Lydia Wachsmuth, Katrin Schwegmann, Stefan Wagner, Klaus Kopka, Monika A Jarzabek, Patrick Dicker, Sven Hermann, Cornelius Faber, Tim Klasen, Michael Schäfers, David O'Brien, Jochen HM Prehn, Andreas H Jacobs and Annette T. Byrne.

» read more


Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant.

British Journal of Cancer 114, Pages 188-198, 19 January 2016
DOI: 10.1038/bjc.2015.420

Zakaria Z, Tivnan A, Flanagan L, Murray DW, Salvucci M, Stringer BW, Day BW, Boyd AW, Kögel D, Rehm M, O'Brien DF, Byrne AT, Prehn JH.

» read more


Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase 3 GeparQuinto study.

International Journal of Cancer Vol 137: 12, pages 2981-2988, 15 December 2015.
DOI: 10.1002/ijc.29656

Alexander Hein, Diether Lambrechts et al

» read more


Integrating Colon Cancer Microarray Data: Associating Locus-Specific Methylation Groups to Gene Expression-Based Classifications

Microarrays 4(4), 630-646, 23 November 2015.
DOI: 10.3390/microarrays4040630

Ana Barat, Heather J. Ruskin, Annette T. Byrne and Jochen H. M. Prehn.

» read more